Ceglie Messapica (Italian pronunciation: [ˈtʃɛʎʎe mesˈsaːpika]; Brindisino: Cégghie) is a town, and comune, located in the province of Brindisi and region of Apulia, in southern Italy, in the traditional area called Salento.

The area of Ceglie Messapica is located between the Murge and the Upper Salento: its typical elements include trulli, farms, lamie (typical southern single room square dwellings), rupestrian churches, Carsic caves, dolinas, specchie and paretoni (remains of city walls), dry-stone walls, olive groves, vineyards, maquis shrub, ancient oak trees, cattle pastures and arable land.

Nearby the village were extra-urban sanctuaries dedicated to the God Apollo (near the modern church of San Rocco) and Venus (on the Montevicoli hill).

In Roman times it was already decaying, and in the Middle Ages was a small village known as Celie de Galdo, with a little castle.

The SP581 provincial road connects the commune with Martina Franca to the west and San Vito dei Normanni to the east.