[1] Mesaieed was established in 1949 as a tanker terminal by QatarEnergy on a previously uninhabited site along the coast.

It was chosen by the company because of its proximity to the working population in Doha and Al Wakrah and because of the depth of its waters.

They installed industrial facilities, mechanical equipment and developed the road system at an estimated cost of $200 mn.

[8] The rapid growth of oil revenues in the 1960s and the accession of Khalifa bin Hamad Al Thani in 1972 resulted in the government assuming a portion of control over the area.

[6] In June 2016, it was announced that QatarEnergy would transfer portions of Mesaieed Industrial Area to the Economic Zones Company Qatar (Manateq), effective January 2017.

[11] The area accommodates the main plants of the following companies: In 1969, a decision was reached to construct Qatar's first flour mill in Mesaieed.

[14] A 1350 MW natural gas power plant has also been built to ensure a stable supply of electricity.

[1] Urea and ammonia production is regulated by Qatar Fertiliser Company, the only fertilizer producer in the country.

It was staffed mainly by employees of Norsk Hydro in its initial years, with whom it had signed a long-term cooperation agreement.