Meshoppen Creek begins on a hill in Bridgewater Township, Susquehanna County.
After a short distance, the creek completely enters Dimock Township and continues south and west for several more miles.
In the southern edge of the township, it passes through a lake and receives the tributary Burdlick Creek.
It continues meandering southwest, crossing Pennsylvania Route 29, entering Washington Township and passing Valentine Hill.
[1] Meshoppen Creek joins the Susquehanna River 234.44 miles (377.29 km) upstream of its mouth.
Large numbers of riffles and few pools area also found downstream of Pennsylvania Route 29.
Steep but rounded hills are present in the watershed, as are forests and some swamps and lakes.
[4] Meshoppen is a name derived from a Native American language purported to mean "glass beads".
[6] In the early 1900s, major industries in the watershed of Meshoppen Creek included agriculture, quarries, and sawmills.
The Lehigh Valley Railroad also went through the watershed in this time period and used the creek as a water supply.
[5] A total of 17.0 miles (27.4 km) of Meshoppen Creek are possible to canoe on during snowmelt or within several days of heavy rain.