Mesodma is an extinct genus of mammal, a member of the extinct order Multituberculata within the suborder Cimolodonta, family Neoplagiaulacidae.

It lived during the upper Cretaceous and Paleocene Periods of what is now North America.

The earliest definitive record is from the late Santonian stage strata of the Straight Cliffs Formation.

[1] A single premolar tooth from the lower Cenomanian stage strata of the Cedar Mountain Formation has been tentatively assigned to this genus based on its similarity, but its describers noted that it is unlikely that Mesodma lived during that time.

[2] The species "Mesodma" primaeva from the Judithian of Western Interior of North America was formerly assigned to the genus Mesodma, but subsequently it was made the type species of a separate genus Filikomys.