The school is a member of the Arizona Interscholastic Association's 4A - Desert Sky Conference and competes in Division II and III sports.

The marching band repeated its Division III State Championship in 2015 with the show "Luna Mysterium."

On the morning of October 24, 2007, Assistant Band Director Christopher Rainer was killed in a car accident.

On May 11, 2011, a piece commissioned by Richard L. Saucedo was performed to commemorate Rainer at Mesquite High by the top concert band, Wind Ensemble.

[9] In addition to its own school logo, Mesquite frequently uses Kansas State University's Powercat symbol.

As part of the licensing agreement between Mesquite and Kansas State, the student council donates $500 to the university every two years.