Messey-sur-Grosne (French pronunciation: [mesɛ syʁ ɡʁon], literally Messey on Grosne) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.

The Goutteuse flows southeast through the middle of the commune, crosses the village, then flows into the Grosne, which forms the commune's southeastern border.

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