MetaZoo centers around creatures known as Beasties who are inspired by cryptids and other figures from mythology and folklore such as Bigfoot, Mothman, Piasa Bird, the Chupacabra and other fearsome critters.

[1] On January 29, 2024, MetaZoo Games founder Michael Waddell wrote on the company's Discord it was shutting down production effective immediately.

They have a minimum of 40 and no designated maximum of cards as long as players are able to be shuffle them with two hands and no additional or external assistance.

[8] MetaZoology refers to the official body of tournament rules, policies, guidelines, sanctions and best-practices that are implemented in organized play.

MetaZoology was created as a means to maintain order and communication on both official and local sanctioned game matches in coordination with tournament organizers and the MetaZoo PlayNetwork.

[10] The second edition of the event was intended to take place on Thursday, October 12, 2023, during the New York Comic Con[11] but was canceled due to logistical issues.

[14] The next event will be the Dark Tower which will take place in September during the 2023 Mothman Festival in Point Pleasant, West Virginia.

The first Beasties to be featured are based on paranormal sightings, folktales, indigenous mythologies and pop culture from North America, particularly Canada, the United States and its territories.

[3] MetaZoo follows a storyline centered around the character of Sam Sinclair, a prodigious Caster from Point Pleasant, West Virginia, who is on a quest across North America to restore order to the world that has been thrown into chaos after the rupture of the Great Veil by the villainous Indrid Cold.

Some of the Beasties featured in Cryptid Nation: Nightfall are the Beast of Bladenboro, the Bell Witch, the Black-Eyed Children, the Boogeyman, the Dark Watchers, the Dover Demon, the Grim Reaper, the Headless Horseman, Robert the Doll, and the Wendigo.

[17] Released on March 31, 2022, Cryptid Nation: Wilderness focuses on Forest Aura Beasties and introduces original characters such as Rosie Robinson.

Rather than focusing on any specific Aura type, this set pays homage to the rich folklore and diverse mythology of numerous indigenous American tribes and ethnic groups across Canada, the United States, Greenland and Puerto Rico.

Some of the featured Beasties include Achiyalabopa, Ahkiyyini, the Akhlut, Ask-wee-da-eed, Atabey, the Awakkule, Azeban, the Canotila, the Chepi, Djieien, the Dzoavits, the Haakapainiži, the Haietlik, Hé-no, Iktomi, Issitoq, the Jogah, the Mannegishi, Nanook, Nun'Yunu'Wi, Odziozo, Ogopogo, the Raven Mocker, Sedna, Skookum, Tupilaq, the Uktena, the Wendigo, Yehashuri, and Yokahu.

The cards of this set feature Hiro and other characters belonging to five factions called melodias which correspond to the five musical interludes in which the album is divided into.