Metaclazepam[1] (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative.

[2][3] It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.

[9] Metaclazepam can interact with alcohol producing additive sedative-hypnotic effects.

[6][10] Fatigue is a common side effect from metaclazepam at high doses.

[11] Small amounts of metaclazepam as well as its metabolites enter into human breast milk.