Metaescaline (3,4-dimethoxy-5-ethoxyphenethylamine) is a lesser-known psychedelic drug.

Metaescaline was first synthesized by Alexander Shulgin.

In his book PiHKAL, the dosage range is listed as 200–350 mg, and the duration listed as 8–12 hours.

[1] Metaescaline produces mental insights, entactogenic, MDMA-like effects, and TOMSO-like activation.

Little data exists about the pharmacological properties, metabolism, and toxicity of metaescaline, though it has been studied to a limited extent in comparison with other related compounds.