Methedrone (para-methoxymethcathinone, 4-methoxymethcathinone, bk-PMMA, PMMC, methoxyphedrine, 4-MeOMC) is a recreational drug of the cathinone chemical class.

In both cases toxicology analysis showed methedrone was the only drug present in both men during the time of their overdose and subsequent deaths.

According to users, a single dose of Methedrone varies from 50 to 500 mg with effects lasting 45 minutes to two hours.

In the second body the concentration in the femoral blood sample was 9.6 μg/g, with Methedrone being the only toxic compound detected.

These studies show that the therapeutic index (or safety ratio) is low compared to other illegal drugs like Amphetamine.

[3] Anecdotal and case reports of human use of "bath salts", such as methedrone, suggest that these substances produce powerful psychological effects.

[6] Methedrone was almost immediately withdrawn from sale by initial vendors after reports of adverse health effects.

[citation needed] Some amphetamine analogs containing a para-methoxy group are known to cause severe hyperthermia and even death due to concurrent MAOI and monoamine releasing action.

[5] Also, the lethal doses found in the two Swedish methedrone-victims have been compared to the methedrone concentrations in the blood of two other males dying in similar conditions.

It is suggested that methedrone increases salivation via brain systems that primarily regulate autonomic responses.

[3] No studies have examined the effect of methedrone use during or before pregnancy by a pregnant female on the embryo, nor is the carcinogenicity researched.

The resulting lack of inhibition despite its proclivity to release DAT can lead to a life-threatening adrenergic storm.

Because, when tested directly in blood or urine, it is not known whether the compound will be degraded by enzymes available in the biological solutions or cause the chemical mechanisms, such as pH or dissolved oxygen.

The length of the half-life of the compound has been examined and the percent remaining after 12 hours in buffers with various pHs.

Another conclusion based on the results from the literature is that there is negative charge built up in the transition state during the rate determining step.

[21] Methedrone can be purchased legally in Europe (excluding Sweden) and in most states in the US on the Internet, but also it can also be found at head shops and other retailers.