In the course of studying she played the roles of Katerina (Feodor Sologod's Penny Plucked) and Anani (Gabriel Sundukian's Once Again Another Victim[1]).
Among the first memorable roles are Armanush (Grigor Ter-Grigoryan's These Stars are Ours, Stalin Prize, 1950), Nina (Mikhail Lermontov’s Masquerade, Arbenin, Vahram Papazian).
Simonyan continued Arus Voskanyan and Ruzanna Vardanyan's traditions in the Armenian theatre.
Metaksya Simonyan was a leading actress for decades, characters she played include: Shura (Maxim Gorky's Yegor Bulychov and Others), Desdemona, Juliet, Cordelia (William Shakespeare's Othello,[2] Romeo and Juliet, King Lear), Susan (Alexander Shirvanzade’s Namus) Then she played the roles of Hudit (Karl Gutzkow's Uriel Acosta), Noudar (Nairi Zarian’s Ara Beautiful), Catherine Leffier (Victorian Sardou and Madame San Jen of Ezezip Moro), Martha (Edward Albee’s Who's Afraid of Virginia Woolf, last role), etc.
Metaksia Simonyan has been shotted in cinema (Anahit, 1947, "A Girl From Ararat Valley", 1949, To Whom The Life Smiles, 1957, A Jump Over the Precipice in 1959, Waters Rise, 1962, The Last Deed of Kamo, 1973, Hayfilm, Sayat-Nova, 1960, TV movie, etc.).