The name is a combination of the Greek word for change (meta) and the class of fiber that it utilizes (mucilage).

In its early years, Metamucil achieved sporadic drug-store distribution as a "behind the counter" brand.

The brand is sold as powdered drink mixes, capsules and wafers in a variety of flavors.

Procter & Gamble sought to make Metamucil a household name by advertising in magazines and on television, using the claim "All fiber is not created equal".

On October 4, 2013, Procter & Gamble partnered with Tony Danza to organize the “Do More Than You Think”[3] contest to promote and fund health and wellness charities.