It is a mockbuster of the film Cocaine Bear by Elizabeth Banks.

[3] In February 2023, the day of the release of Cocaine Bear, The Asylum announced the film on Twitter under the working title of Attack of the Meth Gator.

[2][4][5] The next day, in a Tweet by The Asylum featuring a video of cast members complaining about the fictional titular alligator, it was confirmed that filming had completed on February 25.

[7] Meth Gator is loosely inspired by reports from 2019 that a Tennessee police department publicly discouraged the flushing of methamphetamine down toilets due to the possibility that alligators could ingest the drug, creating hyper-aggressive "meth gators".

[4][5][8] At the time of the reports, Kent Vliet, an alligator biologist at the University of Florida, denied the existence of so-called meth gators, stating that it was a "ridiculous notion".