On October 19, 1995, after the death of Patriarch of Kyiv and All Rus-Ukraine Volodymyr, bishop Mefodiy confessed the jurisdiction of the Ukrainian Autocephalous Orthodox Church.

On March 1, 2000 by the decision of the IV Local Council of Ukrainian Autocephalous Orthodox Church Mefodiy was elected Locum Tenens of the UAOC Patriarch throne.

On 2002 at the urging of Ukrainian Autocephalous Orthodox Church Bishops' Council, Mefodiy assumed the title of "Metropolitan of Kyiv and All Ukraine."

Since his elevation, he has worked towards global visibility for the church, including a pastoral visits to the United States in 2006 and traveled to Western Europe.

In 2005, Metropolitan Mefodiy pursued a legal suit which successfully restored the patriarchal chancery offices and the Church of Saint Demetrius of Thessaloniki to the UAOC.

On October 18, 2008, the first diplomas of the newly accredited theological school were awarded to qualified graduates in a ceremony in the Cathedral of the Nativity of Christ in Ternopil.

In many documents written by His Beatitude Metropolitan Mefodiy or under his direct supervision, the historical and canonical reasons of contemporary canonical Ukrainian Orthodox crisis reveals, the key mistakes of the autocephalous movement are identified and ways to overcome them and to enter the communion with the Ecumenical Patriarchate of Constantinople are proposed.