Methylergometrine, also known as methylergonovine and sold under the brand name Methergine, is a medication of the ergoline and lysergamide groups which is used as an oxytocic in obstetrics and as an antimigraine agent in the treatment of migraine headaches.

[9] Adverse effects include:[3] In excessive doses, methylergometrine can also lead to cramping, respiratory depression and coma.

[11][12][13][14] Methylergometrine is a synthetic analogue of ergometrine, a psychedelic alkaloid found in ergot, and many species of morning glory.

Methylergometrine is a member of the ergoline family and chemically similar to LSD, ergine, ergometrine, and lysergic acid.

[citation needed] Clinical efficacy occurs around 200 μg, ten times lower than the hallucinogenic threshold.