[3] The first segment of the network opened to the public in May 2011, and runs all the way along Juan B. Justo Avenue linking the neighbourhoods of Liniers and Palermo.

The system's signage and bus stops were designed by Diana Cabeza, Martín Wolfson, and Gabriela Falgione.

[6][7] The second segment of the network, opened on 24 July 2013, spans the length of the 9 de Julio Avenue, consisting of 17 stations running for 3 kilometres (1.9 mi).

In parts of this segment of the network (along Rabanal Avenue) the bus lines merge with the general traffic and return to the dedicated lane afterwards.

[4] It is 12 kilometres (7.5 mi) long, has 21 stations and carries 100,000 passengers per day with a frequency of one bus every 2 minutes.

The implementation of this Metrobús line was met with some criticism from shop owners along the avenue who could no longer receive deliveries during peak hours due to the lower number of lanes for regular traffic, something which has been remedied by having specific hours for deliveries.

[15] The main objective of this line is to join together the city's two busiest railway stations: Retiro and Constitución and to serve the approximately 250,000 passengers per day which use buses along the avenue.

[21][22] The line is estimated to carry around 250,000 passengers per day, with its creation increasing rider-ship by 30% and reducing journey times by 15%.

[9][25] It has a length of 2.1 kilometres (1.3 mi) and was designed to reduce congestion in the area because of the number of passengers that were boarding Line D, whilst creating a terminal at the limits of the city at General Paz Highway for passengers from suburbs in Northern Greater Buenos Aires, such as Olivos and Vicente López.

[28] The line has significantly different characteristics to the rest of the network, consisting of a single six-metre lane in the middle of the 25 de Mayo activated only during rush hour and shared with emergency vehicles.

[31] Along with the Metrobús line, the construction of a second bus terminal to reduce the strain on the Retiro bus terminal (by an estimated 40%) is being constructed at the start of the Metrobús line, at the intersections of the Dellepiane and 25 de Mayo expressways, with the intention of reducing the quantity of long distance buses making their way into the centre of the city.