The first of the two roads connects San Martín Texmelucan, Puebla to El Molinito, northeast of Tlaxcala City and southwest of Apizaco.

The road is operated by Promotora y Operadora de Infraestructura S.A. de C.V. (PINFRA).

A toll of 63 pesos per car is charged to travel between Texmelucan and Tlaxcala.

[2] The 11 kilometres (6.8 mi) Libramiento de Tlaxcala serves as a southern bypass of the city, connecting the highway to Texmelucan, the state toll road between Puebla and Tlaxcala, and Mexican Federal Highway 121.

[3] The bypass's construction began in 2009, with three kilometers remaining unfinished from 2012 to 2015.