Mexico made its Paralympic Games début at the 1972 Summer Paralympics in Heidelberg, with a delegation of seven athletes competing in track and field, swimming, weightlifting and wheelchair fencing.

Although Mexicans did not win any medals at the 1972 Games, they swept up sixteen gold (fifteen in athletics, one in swimming) in 1976, along with fourteen silver and nine bronze, and continued to win medals during every subsequent edition of the Summer Games.

[4] Among the most successful Mexican Paralympians, Josefina Cornejo won four gold medals in track and field at the 1976 Games, reiterating that result four years later.

[5] Mexican delegations to the Winter Games, by contrast, have been small (one competitor in 2006, two in 2010, one in 2014 and one in 2018), and have not won any medals.

This article summarising a nation's participation in the Paralympic Games is a stub.