Mezhdurechye (Russian: Междуречье) is a rural locality (a settlement) in Vtorokamensky Selsoviet, Loktevsky District, Altai Krai, Russia.

Mezhdurechye is located on the Kamenka River, 32 km northeast of Gornyak (the district's administrative centre) by road.

Gilyovo is the nearest rural locality.

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