The school serves ninth through twelfth grade students in a mostly unincorporated suburban and rural area in the southern stretches of Miami-Dade County between South Miami and Homestead.

Miami Southridge was the zoned high school for Cutler Bay prior to 2012.

[3][4] In 2009-10, Miami Southridge Senior High School's student body was 48.2% Hispanic (of any race), 40.3% Black, and 8.7% non-Hispanic White.

Smaller groups included Asian, Indian, and multiracial ethnicities.

[5] In 2011 Perry Stein of the Miami Herald described Southridge as "a low-performing school".