He is director of Forensic Rehabilitation Research at the Royal Ottawa Health Care Group, where his research focuses on pedophilia, sexual offenses committed against children, child pornography, risk assessment, offenders with mental disorders, psychopathy, and program evaluation.

[3] He serves as Scientific Advisor to Thorn,[4] a company that partners across the tech industry, government and NGOs and leverage technology to combat predatory behavior, rescue victims, and protect vulnerable children.

Seto has been noted as "one of the foremost authorities" on adolescent sex offenders[5][better source needed] and on people with pedophilia.

[6] Seto defined the term mesophilia, a chronophilia involving attraction to middle-aged adults in their 40s and 50s, in a 2017 literature review.

Rather, "They are seeking out children who will be more receptive to their approach—children who may be socially isolated, impoverished, lacking a father figure.

[9] There also appears to be an age difference, according to Seto: "People on average under 35 are more familiar with the technology than those who are over 35, and the arrests reflect that.