Lockshin's long-term research interest is in the clinical aspects of systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), pregnancy in rheumatic disease patients, gender and rheumatic disease, and neurological SLE.
Guarded Prognosis: A Doctor and his Patients Talk about Chronic Disease and How to Cope With It (Hill and Wang, a division of Farrar, Straus and Giroux) was published in 1998.
His latest book, The Prince at the Ruined Tower: Time, Uncertainty & Chronic Illness explores seldom discussed issues of contemporary medical practice, such as how patients, doctors, insurers, and administrators should and do respond when diagnoses are uncertain.
Lockshin held senior management positions at the National Institutes of Health in Bethesda, Maryland.
Lockshin has served on numerous study sections and ad hoc committees for the National Institutes of Health, the Veterans' Administration, the Canadian Arthritis and Rheumatism Society, the Canadian Medical Research Council, the SLE Foundation, among others.
He chaired the ACR's Audiovisual Aids Committee that produced the first Clinical Slide Collection in rheumatology.