Dorn has appeared more times as a regular cast member than any other Star Trek actor in the franchise's history, spanning five films and 284 television episodes.

Following his graduation, he pursued a career in music as a performer with several different rock-music bands, traveling to San Francisco and then back to Los Angeles.

[4] His character proved so popular amongst fans that Dorn was added to the cast of spin-off series Deep Space Nine in an effort to boost ratings.

In 2014, he participated in the fan-produced Star Trek episode "Fairest of Them All", giving his voice to the computer of the Mirror Universe Enterprise.

In 2012, Dorn announced a desire to return to his Klingon role in a television series tentatively titled Star Trek: Captain Worf.

Dorn reprised his role as Worf for cameo appearances on Webster and Family Guy, the latter with several of his fellow Next Generation castmates.

He had a recurring role on the television series Castle, playing the therapist of NYPD police detective Kate Beckett's.

[12] In March 2023, Dorn was announced as the writer for a comic starring Steel (John Henry Irons), whom he voiced in Superman: The Animated Series.