During his tenure, he expanded the theatre's repertoire to include European work, touring productions and an extensive education programme, as well as taking the new Donmar brand to international audiences in America, Australia, Argentina and Europe.

In September 2008, he launched a one-year Donmar West End "access for all" season of four plays with affordable ticket prices when the company extended its repertory to the newly refurbished Wyndham's Theatre.

Grandage directed all four productions: Kenneth Branagh in Ivanov, Derek Jacobi in Twelfth Night, Judi Dench in Madame de Sade and Jude Law in Hamlet.

[6] In 2010, he launched a three-year West End season at the Trafalgar Studios to highlight the work of young directors who emerged from the Donmar's training scheme during his tenure.

He was first nominated for a Laurence Olivier Award in 2001 for Best Director for Peter Nichols' Passion Play at the Donmar Warehouse before winning in 2004 for David Greig's Caligula.

He has won four Evening Standard Awards for his Donmar work including productions of Passion Play, Merrily We Roll Along, Grand Hotel, Ivanov, The Chalk Garden and Othello.

In June 2012 he announced a fifteen-month season of work at the Noël Coward Theatre in London's West End aimed at reaching out to a new generation of theatre-goers through pricing and access with over 100,000 seats going on sale at £10.

Directed by Jeremy Herrin and starring Martin Freeman and Tamsin Greig, this critically acclaimed production went on to win the 2017 Olivier Award for Best New Comedy.

[27] In 2018, they continued their commitment to quality work at affordable prices in the West End presenting Red by John Logan and The Lieutenant of Inishmore by Martin McDonagh – both directed by Grandage.

Also in 2018, MGC announced a new film in development based on David Pitts' book Jack and Lem: The Untold Story of an Extraordinary Friendship.

[31] In 2023 MGC produced Orlando from the novel by Virginia Woolf in a new adaptation by Neil Bartlett, starring Emma Corrin and directed by Michael Grandage at the Garrick Theatre.

It played a twelve week run at the Duke of York’s Theatre, directed by Michael Grandage and earning Dos Santos a Critics' Circle Award.

The film, which was based on A. Scott Berg’s biography Max Perkins: Editor of Genius, had a screenplay by John Logan and was directed by Grandage.

It starred Colin Firth, Jude Law, Nicole Kidman, Guy Pearce, Dominic West and Laura Linney and premiered at the Berlin Film Festival before a release on 16 June 2016 in the US.

[37] The charity's patrons include Dame Judi Dench, Dawn French, Nicole Kidman, Jude Law, Daniel Radcliffe, Sir Simon Russell Beale,[38] Aidan Turner and David Walliams.