Michael Keppele (September 9, 1771 – February 2, 1821)[citation needed] was a lawyer, alderman, and mayor of Philadelphia, 1811–1812.

He was elected mayor on October 15, 1811, and served a one-year term.

He married Catherine Caldwell (June 7, 1774 – August 23, 1862).

Their daughter Sarah Caldwell Keppele (1789–1877) married James Cornell Biddle (1795–1838), of the Philadelphia Biddle family in 1825.

He was son of revolutionary war soldier Clement Biddle (1740–1814).