He founded Edwin H. Fitler & Company, the largest cordage manufacturer in the United States at the time, and served as a Republican Presidential Elector for Pennsylvania in 1876 and mayor of Philadelphia from 1887 to 1891.

Displaying an aptitude for mechanics, Fitler developed several inventions to improve and speed up rope making, which made the business more profitable.

Recognized as a leader in his industry, Fitler served as president of the American Cordage Manufacturers Association.

[5] Fitler was also active in other businesses, including as a member of the board of directors of the National Bank of the Northern Liberties.

Though he was not an active candidate, in 1888 Fitler was nominated for US president and received the votes of the Philadelphia delegation on the first ballot at that year's Republican national convention.