"[2] His work has appeared in The New Yorker, The New York Times, LA Weekly, The Wall Street Journal, Screw, Fortune, The Independent on Sunday, Libération, Nickelodeon Magazine, The Believer, and Heavy Metal, as well as in comics anthologies such as Hotwire, Snake Eyes, Zero Zero, Hyena, Hodags and Hodaddies, Blood Orange, Rosetta, 106U, and Legal Action Comics.

[3] When Michael was young, between ages ten and twelve, he was fascinated with editorial cartoons, particularly the work of Pat Oliphant.

Parts of his work were animated later that year for the Comedy Central show TV Funhouse, produced by Robert Smigel and Dino Stamatopoulos.

[1] In 2005, he started a comic book series called Tales Designed To Thrizzle, published by Fantagraphics.

As of 2009, Kupperman is writing sketches for a new comedy series starring Peter Serafinowicz,[4] and he created a one-off pilot called Snake 'N' Bacon for the Adult Swim network.