In domestic cricket, he represents Queensland, and the Brisbane Heat in the Big Bash League, as well as Glamorgan in the County Championship, Royal London One-Day Cup and T20 Blast.

Neser was born in Pretoria, South Africa,[1] but moved to Queensland, Australia, with his family when he was 10 years old, settling on the Gold Coast.

[2] There he began playing junior cricket for the Broadbeach-Robina Cats and made his first grade debut for the Gold Coast Dolphins at 17 years of age in February 2008.

[2] In the inaugural season of the Big Bash League, Australia's new Twenty20 tournament, Neser played for Queensland's new team, the Brisbane Heat.

[9] As a result of his form for the Heat in BBL|01 and the Strikers in BBL|02, Neser was given a shock contract with the Kings XI Punjab in the Indian Premier League.

[27] In December 2022, Neser was recalled to Australia's Test team along with Scott Boland after Pat Cummins and Josh Hazlewood were ruled out due to injury, recording match figures of 5/56 and scoring 18 runs in his only innings with the bat.

Despite the strong performance, Neser was left out of the XI for Australia's next Test series against South Africa in favour of Boland as Cummins returned to fitness.