Michael was the governor of Mesembria and claimant of the Empire of Trebizond.
He was born sometime after 1351, as the third or fourth son of John V and his wife, Helena Kantakouzene.
He was married to a Bulgarian princess, daughter of Dobrotitsa, and was raised to the rank of Despot at an unknown date.
[1][2] In 1366, Michael accompanied his father to his visit to Buda, the capital of the Kingdom of Hungary, where he sought aid against the Ottoman Turks.
His fleet of three ships laid at anchor outside the city's harbor for five days, when he sailed back in failure.