Michael "Mike" Thompson (b. on June 16, 1977 in Akwesasne, Ontario) is an Iroquois retired professional box lacrosse player.
Thompson played seven seasons in the National Lacrosse League, six with the Buffalo Bandits.
He signed with the Bandits on August 18, 2006 to replace Ken Montour as back-up goalie to Steve Dietrich.
In 2008, Montour came back to Buffalo, he and Thompson formed a goalie platoon for the Bandits leading to the franchise's fourth NLL Championship.
Thompson would make 39 saves, including one as time expired, as he went the whole way in the 2008 Champion's Cup.