Vehe was born in Biberach (now part of Heilbronn, near Bad Wimpfen).
He joined the Dominicans in Wimpfen and was sent to Heidelberg in 1506, where he taught in 1512 and received a doctorate in theology in 1513.
In 1515 he was appointed regent of the Dominican house of studies at Heidelberg; later Cardinal Albert of Mainz chose him as theologian and put him in charge of the church of Halle, Saxony.
view Vehe's writings as the best apologetical treatises that appeared in Germany during the sixteenth century.
The songs in Vehe's collection eventually formed the basis for all later Catholic hymnals.