Michel Duflo (born 15 August 1943) is a French mathematician who works in the representation theory of Lie groups.

From 1962, Duflo studied at the École normale supérieure and received a doctorate under the supervision of Jacques Dixmier.

Currently, he is an emeritus professor at the University of Paris VII (Denis Diderot) at the Institut de Mathématiques de Jussieu, and at the École normale supérieure.

Duflo has worked on the orbit method of Alexander Kirillov.

In 1974 he was an invited speaker at the International Congress of Mathematicians in Vancouver (Inversion formula and invariant differential operators on solvable Lie groups).