The son of an architect, he entered the École des Beaux-Arts, Lyon in the studio of Tony Garnier and then became a student in the workshop of Gaston Redon and Alfred Henry Recoura at the National School of Fine Arts in Paris.
Influenced by Auguste Perret, he made a characteristic building of his style - with bay windows to 3 sides on the front - at 14 Guynemer street in Paris.
He was appointed editor in chief of The Architect between 1925 and 1932, then joined the Board of Patrons of the journal L'Architecture d'aujourd'hui in 1930.
[1] Roux-Spitz used these various forums to defend the position of modern architects, but opposed the radical principles of Le Corbusier.
He was chief architect of the National Library in 1932 and remained so until 1953, in this post making a rearrangement within the current Richelieu site and construction of an annex to Versailles.