Born in Rome to parents who originated from Palermo, Gammino began his career during the early 1970s.

For his work on Italian television, Gammino has become famous on a number of occasions but mostly as presenter of Giochi senza frontiere, the Italian edition of Jeux sans frontières, which he co-hosted with Ettore Andenna and Milly Carlucci between 1979 and 1982.

Gammino continued to act for television, he provided newly restored voices in a series of Italian films which include Le ragazze di Piazza di Spagna, Carabinieri 7, Una donna per amico, Linda e il brigadiere, Un medico in famiglia and the third season of I Cesaroni.

[2] He has even dubbed over 40 characters in films portrayed by actors such as Kevin Costner, Bill Murray, Jack Nicholson, Chevy Chase, Chazz Palminteri and Bob Hoskins.

In Gammino's animated roles, he dubbed the voices of Nando in Asterix and Cleopatra and Dr. Jekyll and Mr. Hyde in The Pagemaster.