Michele Piccirillo (born 29 January 1970 in Modugno, Italy) is a professional boxer in the welterweight (147 lb [66.7 kg]) division.

Michele Piccirillo was an Italian boxer who earned the nickname “Il Gentleman del Ring” for his elegant fighting style and sportsmanship.

In his 11th pro contest in 1994 he won the Intercontinental Light-Welterweight title against the Mexican Manuel Hernández, then on 21 July 1995, he became Italian champion against Franco Palmiero.

He rebounded to win the vacant European light-middleweight title against Lukáš Konečný, then defended it twice against Luca Messi and Michael Jones.

On 1 December 2007, at Foxwoods Casino in Mashantucket, Connecticut, he tried again to win the world title, but was knocked out in round 11 by the American Vernon Forrest.