[1] Since the early 2010s, she has directed several documentaries, including her feature film directorial debut, Alias (2013),[2] and the Viceland series, Rise, which focuses on the 2016 Dakota Access Pipeline protests; the latter won a Canadian Screen Award at the 6th annual ceremony in 2018.

[10] After Paradise Falls, she returned to the stage, starring in Unidentified Human Remains and the True Nature of Love, written by Brad Fraser.

[13] In 2013, she made her feature film directorial debut Alias, which "follows aspiring rappers trying to escape the gangster life.

[18] Latimer's Viceland documentary series, titled Rise, which focuses on the 2016 Dakota Access Pipeline protests, premiered at the Special Events section of the 2017 Sundance Film Festival.

[3][4] While accepting the award, Latimer delivered what was described by CBC News as "one of the night's most passionate speeches", in which she celebrated Indigenous resistance at Standing Rock.

[24][25][26] The series centres on Jared, an Indigenous Haisla teenager and small-time drug dealer in Kitimat, British Columbia, who becomes increasingly aware of the magical events that seem to follow him.

[21] Adapted from Thomas King's non-fiction book The Inconvenient Indian, the film presents a history of the indigenous peoples in Canada.

[30] The film blends scenes in which King, filmed in a taxi cab being driven by actress Gail Maurice in character as an indigenous trickster, narrates portions of his own book, blended with video clips of historical representation of indigenous peoples as well as segments profiling modern figures, such as Kent Monkman, Christi Belcourt, A Tribe Called Red, Alethea Arnaquq-Baril and Nyla Innuksuk, who are reshaping the narrative with their contemporary work in art, music, literature and film.

[7] Through much of her career, Latimer identified as having Algonquin and Métis heritage, based on a family oral history of Indigenous ancestry in the province of Quebec.

[33] In a September 2020 interview about her film and TV projects, she stated that her mother had a complicated relationship with her mixed race identity.

[35] Latimer subsequently apologized for having claimed historical roots to the Kitigan Zibi community before fully verifying them,[33] and resigned from the production of her television series Trickster,[36] after the husband and wife producing team of Tony Elliott and Danis Goulet resigned from the show, citing the questions and criticism about Latimer's ethnic identity as their reason.

[35][38] Later, Sébastien Malette, an associate professor in the Department of Law and Legal Studies at Carleton University, and Siomonn Pulla, an associate professor in the College of Interdisciplinary Studies at Royal Roads University produced a joint genealogical report which found that Latimer has Indigenous ancestry from both her paternal and maternal lines that originated from a "historical community of Baskatong that was known for its Algonquin and Métis population.

An Algonquin Elder from Kitigan Zibi, Annie Smith St. Georges, (known for her work with the National Arts Centre) posted on Facebook that Latimer was connected with her indigenous ancestors by marriage, "the grand niece of my grandpa and grandma, who were originally from Mishomis Baskatong.