Thereafter, she was cast in several TV shows in the network, particularly in the youth-oriented drama SCQ Reload and the fantasy horror series Spirits along with Vietnam Rose, Crazy for You, Maging Sino Ka Man and Sineserye Presents: May Minamahal.

Recently, Michelle played Juana Manalo In Zorro and she will include in Sine Novela: Tinik sa Dibdib which stars Sunshine Dizon (later Nadine Samonte) as Lorna Yadao-Domingo, where she played the only crazy but humble sister in law of Trixie (Ara Mina, later Rita (Sheryl Cruz) Moret or Corazon Domingo.

In 2015, Madrigal returned to ABS-CBN and appeared in Pasión de Amor (based on Pasión de Gavilanes, produced by Telemundo), co-starring Jake Cuenca, Arci Muñoz, Ejay Falcon, Ellen Adarna, Joseph Marco and Coleen Garcia.

On April 30, 2017, Madrigal announced through Instagram that she and her partner, Troy Woolfolk, had been expecting their first child for three months.

In August 2021, Michelle and her husband confirmed that they separated as they go through their divorce by posting on their respective Instagram accounts.