She mostly appears on TV shows but has also starred in movies, such as Now That I Have You, the Shake, Rattle & Roll film series, and D' Anothers.

Before her transfer to GMA Network in 2012, she returned to showbiz as a brief Talent5 Artist and appeared in Valiente and an episode in Real Confessions.

In 2004, Guinoo joined the popular reality TV show Star Circle Teen Quest aired on ABS-CBN and made it into the group of finalists known as the "Magic Circle of 5", along with co-stars Hero Angeles, Sandara Park, Joross Gamboa, and Melissa Ricks.

[2][3] Her big break came when she was cast in a leading role in the 2007 drama series Sineserye Presents: Natutulog Ba ang Diyos?, with local television stars Dina Bonnevie and Rosanna Roces while also appearing with Gamboa and Jake Cuenca.

[6] In 2008, she took up her first solo lead role on ABS-CBN with a show entitled Ligaw na Bulaklak which aired in an afternoon slot.

[9] Another comedy series she joined that year was in Everybody Hapi over TV5 (replacing ABC 5) as "Jenny", alongside John Estrada, Eugene Domingo, Long Mejia, Alex Gonzaga and Matt Evans.

In 2009, Guinoo starred in the superhero television show Komiks Presents: Flash Bomba with Luis Manzano.

[14] She returned to showbiz with TV5 in 2012 and appeared in Valiente and an episode in Real Confessions before moving to GMA Network same year.