The Michigan Air Line Railway was a railroad company in the United States.

[3] That company was renamed the St. Clair and Chicago Air Line Railroad the same year; no further expansion occurred through 1875.

[3] In 1877, the Grand Trunk Railway took control of the company to prevent a competitor from developing a competing line to Chicago.

It reached Rochester in March 1879, and the Grand Trunk's existing line between Pontiac and Detroit in October 1880.

[1] The Michigan Air-Line Railway, successor to Coe Rail, abandoned its small section in 2010 and 2011.