Somewhat similar in style to the animated series DuckTales, it was based on the continuity of earlier print material starring Mickey, mainly Floyd Gottfredson's stories in the Mickey Mouse comic strip.

These stories usually featured Mickey, with the help of longtime friends Goofy, Donald Duck, Pluto, Minnie Mouse, Horace Horsecollar, and Clarabelle Cow, having adventures in or out of Mouseton against adversaries such as The Phantom Blot, Big Bad Pete, Emil Eagle, and even newcomer villains like Wiley Wildbeest, Ms. Vixen, and Prince Penguin.

The main feature was written by contemporary writers such as Michael T. Gilbert, Marv Wolfman, and others.

The back-up features were reprints of classic Mickey Mouse comic stories.

The bi-monthly book was 128 pages and usually contained three or more longer stories that featured Mickey and various other Disney characters.