[3] The Roman road from Chester to Wilderspool (near the present town of Warrington) passed through or near the village.

There is also evidence of Roman practice camps in the nearby settlements of Hoole Village and Picton.

[4] Mickle Trafford is not mentioned in the Anglo-Saxon Chronicle,[5] but a raised area in a marsh by the River Gowy to the northeast of the present village, was known as the "Isle of Chester".

[8] Mickle Trafford was historically one of four township in the ancient parish of Plemstall, which formed part of the Broxton Hundred of Cheshire.

The small hamlet of Plemstall itself, around St Peter's Church, was within the boundaries of the Mickle Trafford township.

In some cases, including Plemstall, the civil functions were exercised by each township separately rather than the parish as a whole.