She competed at the International Mixed Martial Arts Federation 2014 World Championship in Las Vegas, conquering a bronze medal after three hard fought rounds in the semifinals against the Brazilian Amanda Ribas.
Signed with the South African promotion Extreme Fighting Championship (EFC)[10][11] to make her professional debut in October 2015,[12] she faced Danella Eliasov to gain a unanimous decision win.
[14] After dropping down to strawweight, she went on a five-fight winning streak,[15] mostly by finishing her opponents before the bell ring,[16] taking her to become the first Italian female to fight in European and international events like Cage Warriors,[17] RXF,[18] Brave Combat Federation[19] and Dana White's Contender Series.
[20] At the beginning of 2020 the Spanish promotion AFL announced the first female only MMA event in Europe,[21] with Micol Di Segni as the first contender for the strawweight title.
Micol Di Segni conquered the inaugural strawweight title defeating her opponent with ground and pound strikes during the third round of the main event of the “AFL Valkyries - DiSegni vs Kerouche” card.