Microhydranencephaly (MHAC) is a severe abnormality of brain development characterized by both microcephaly and hydranencephaly.
[1] Signs and symptoms may include severe microcephaly, scalp rugae (a series of ridges), and profound intellectual disability.
It has been suggested that some cases of MHAC are inherited in an autosomal recessive manner via a loss-of-function mutation of the gene NDE1.
[1][2] This article incorporates text from this source, which is in the public domain: "Microhydranencephaly".
Genetic and Rare Diseases Information Center.