Clinically, the particle size of a drug can affect its release from dosage forms that are administered orally, parenterally, rectally and topically.
The successful formulation of suspensions, emulsions and tablets; both physical stability and pharmacological response also depends on the particle size achieved in the product.
[2][3][4][5] The term was coined by Joseph Marius DallaValle in his book Micromeritics: The Technology of Fine Particles (1948).
Characteristics discussed included particle size and shape, packing, electrical, optical, chemical and surface science.
Particle size and surface area influence the release of a drug from a dosage form that is administered orally, rectally, parenterally, and topically.