The museum's collection includes the largest publicly displayed body of artwork by Blackbear Bosin, the late Kiowa-Comanche sculptor and painter.

[1] The museum has a large collection of Alaska Native artwork from the mid-20th century, as well as flags from over 70 American Indian tribes displayed in the Gallery of Nations event space.

[1] The original co-founders of the museum included Betty Nixon, a Kiowa artisan who later served as the chairwoman of the center's board of directors.

[4] The Mid-America All-Indian Center's social services were later abolished, as similar programs could be provided more easily by other agencies, such as the Salvation Army or United Way of the Plains.

[1] The Mid-America All-Indian Center took out a $175,000 loan from the city of Wichita to pay overdue bills and other expenses.

[1] The Wichita government and the Mid-America All-Indian Center also sought to trim costs and cut programs as part of the restructuring.