MyMichigan Health covers a 23-county region with medical centers in Alma, Alpena, Clare, Gladwin, Midland, Mt.

MyMichigan Physicians Group provides urgent care and medical offices in more than 30 specialties and subspecialties.

During the fiscal year 2018, MyMichigan Health contributed $106.1 million towards community benefit initiatives across a 23-county region.

The system's early history is documented in the book A Journey of Caring by Dorthy Langdon Yates.

[17] As of August 1, 2024, the hospital and affiliated sites formerly known as Ascension St. Mary's in Saginaw was renamed My Michigan Medical Center - Saginaw, having been previously acquired by MyMichigan Health group from Ascension Health.