Middleport is a residential and industrial district in the city of Stoke-on-Trent, England.

The Trent and Mersey Canal and a key path of the National Cycle Network run through Middleport.

Clarice Cliff's Newport Pottery, where she produced some of her most famous work, was adjacent to the canal and an artist-designed 12-foot steel markerpost identifies the location.

Middleport is an area that is strategic to the regeneration of the city, as it sits in the centre of a ring of imminent projects totalling around £250m: the Chatterley Valley scheme, the Etruria Valley scheme, the regeneration of Burslem town centre, and a proposed major "park and ride" interchange and business-park on the site of the old Shelton Bar steel rolling-mill.

Middleport piloted a community warden service in 2002 & 2003; as a result, crime dropped by 80 per cent.