Middlesbrough South and East Cleveland is a constituency[n 1] created in 1997 represented in the House of Commons of the UK Parliament since 2024 by Luke Myer of the Labour Party.

[3] The constituency was created in 1997, mostly replacing the former seat of Langbaurgh and consists of the southern outskirts of Middlesbrough (such as Hemlington, Nunthorpe, Coulby Newham, Marton, Easterside and Park End) and those parts of the Redcar and Cleveland district not in the Redcar constituency.

Election results have to date been considerably more close than in the overwhelmingly urban, city seat of Middlesbrough, this instead being a marginal seat, particularly the 2010, 2015 and 2017 results which saw no absolute majority unlike the previous three absolute majorities won by Ashok Kumar of the Labour Party.

In each election to date the fourth-placed and lower candidates have failed to reach 5% of the vote, therefore forfeiting their deposits.

[5] The constituency is at the forefront of Britain's return to growth in output, however the western authority still in 2011 had the highest unemployment claimant count in the North East, having witnessed a decline in the major local industry of production of industrial and heavy duty steel.