[3] In 1988, the Commonwealth of Massachusetts bought the Marist property for the college; new prefabricated buildings were erected there, and the renovated Bedford campus opened in 1992.

In April 2008, the college acquired a former Boston & Maine railroad depot in Lowell, for future use by performing arts programs.

Bordering the town of Billerica, the campus incorporates 11 buildings that house classrooms, laboratories, offices, a library, the Medical Education Imaging Center and the MCC Concert Hall.

[12] Near the Bedford campus, on Concord Road, a historic saltbox-style farmhouse, now called the Middlesex Meetinghouse, is used primarily for college, corporate and community gatherings.

[12] The college's Lowell campus is situated at Kearney Square, in the heart of the city, at the confluence of the Concord River and the Pawtucket Canal.

The recently restored Federal Building, located across Merrimack Street, houses a library, classrooms, a visual arts room, and conference areas.

[12] The college also maintains the historic John Nesmith House, located on Andover Street in Lowell, which is supported by the MCC Foundation.