[6] It is believed that early settlers in Middleton came from Slab Town, a small settlement about 3 miles (5 km) north.

The town was originally called "Jenkins-McCommons Crossing", after Jesse Jenksins and William Taylor McCommons.

These two men came to the area from North Carolina in 1849 and donated the majority of land where Middleton is today.

After the war, only one building, a small log structure that served as a store, was left standing.

Crane Inc. Spray Coating Division, a hardwood sales company, EP Minerals, LLC, makes of cat litter, and El Paso Tennessee Gas.

[11] Middleton hosts a series of annual events including the Fur, Fin and Feather Festival over Labor Day, the "M-Town Variety Show" in March, and an annual Christmas parade and related holiday events each December.

[10] Major thoroughfares Railroad systems Middleton provides residents water and sewer utilities.

Bailey Howell, Basketball Hall of Famer was born and raised in Middleton until attending Mississippi State University.

[13] Howell was a Boston Celtics player, along with Steve Hamer, who was born in Memphis went to high school in Middleton before he attended the University of Tennessee.

[14] Another athlete, Wayne Haddix, was born in nearby Bolivar but attended Middleton High School, he would go on to play for the Tampa Bay Buccaneers.

[15] Jim Stewart and Estelle Axton, the co-founders of Stax Records, were born in Middleton, before moving to Memphis.